abstract |
Compounds having the formula (I): R1R2C(OR3)-Ar1-X-Ar2-Ar3 are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotecti ve agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejecti on and in preventing the formation of atherosclerotic plaques. |