| abstract |
Disclosed are certain compounds of the formula (I): (see fig.I) (wherein preferably R1 can be (see fig.II) , R2 can be H, R3 can be methyl, R4 can be H, -CO2CH3 or -CO2CH2CH3, R5 can be -CO2CH3 or -CO2CH2CH3, Y is oxygen, sulfur or NR7, wherein R7 preferably is hydrogen, benzenesulfonyl, benzoyl, benzyl, acetyl, phenylacetyl, ethyl or methyl, and Z is -(CH2)n-wherein n is 1 or 2) and pharmaceutically acceptable salts or prodrugs thereof, which are .beta.-adrenergic receptor agonists and accordingly have utility as, inter alia, hypoglycemic and antiobesity agents. More specifically, the compounds are selective agonists of .beta.3-adrenergic receptor. These compounds also possess utility for increasing lean meat deposition and/or improving the lean meat to fat ratio in animals, e. g., ungulate animals, companion animals and poultry. |