http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2200537-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e83d93ed02bbd6159e99b5a7796e3686 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D281-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D281-10 |
| filingDate | 1997-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6a41709b4423e9f731c33f53928e5966 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eff92691387490cd791621ad338ba765 |
| publicationDate | 1997-09-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2200537-A1 |
| titleOfInvention | Process for the preparation of a benzothiazepine |
| abstract | Process for the preparation of a 1,5-benzothiazepine derivative, or a salt thereof, of formula 1 where R1 represents H, an alkyl group or an alkoxy group and R2 represents H or a halogen, in which process a propanoic acid derivative of formula 2 where R1 and R2 are as defined above and R3 represents H or an alkyl group is subjected to an intramolecular cyclisation reaction in a non-halogenated solvent in the presence of a carboxylic acid. Preferably, R2 is H and R1 is OCH3. Trichloroacetic acid is preferablky used as .alpha.-chlorinated acid. The benzothiazepine obtained on cyclisation can be subjected to an alkylation reaction and/or an acylation reaction to obtain known pharmaceutical products, in particular diltiazem. |
| priorityDate | 1996-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 39.