| abstract |
The present invention is directed to a process for preparing optically active trans-3-phenylglycidamide compound, which comprises subjecting a racemic trans-3-phenylglycidamide compound of the formula (I) (I) wherein ring A is substituted or unsubstituted benzene, and R1 is H or lower alkyl, to optical resolution using a microorganism having the ability to preferentially hydrolyze one of (2S,3R) isomer or (2R,3S) isomer thereof, and process for preparing an optically active 1,5-benzothiazepine derivative from the thus-obtained optically active trans-3-phenylglycidamide compound. The 1,5-benzothiazepine derivatives of the present invention are useful as medicaments. |