| abstract |
Bicyclolactam compounds represented by general formula (1) (see formula I) wherein: R is oxo or -OR1, where R1 is a hydrogen atom or an aliphatic acyl group having 2 to 6 carbon atoms, benzoyl, toluyl, methoxybenzoyl, dimethoxybenzoyl, or naphthylcarbonyl; A is a group of (2) or (3) (see formula II and III) wherein R2 is a benzoyl group or a benzoyl group substituted by a halogen atom, lower alkyl group, lower alkoxyl group, nitro group, cyano group, hydroxyl group or amino group; Q is a hydrogen atom or lower alkyl group; 1 is 1 or 2; m is 0 or 1 and n is 0, 1 or 2 (provided the case where both of m and n represent 0 simultaneously is excluded); are useful as the active ingredient of medicines having an excellent anxiolytic effect with little side effects such as hypnotic effect, a muscle relaxing effect and a sedative effect. |