http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2195256-C
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b4a36745ea42b4bcee2aef2ba3d47a28 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S435-81 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-58 |
| filingDate | 1997-01-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2002-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b92f7f5e87d4ac0718e2f3c09dd0da2f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c54a0f857ec8a1660937bb7738ea4ed2 |
| publicationDate | 2002-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2195256-C |
| titleOfInvention | Solid support reagents for the direct synthesis of 3'-labelled polynucleotides |
| abstract | The compounds of the invention are exemplified by the class of diglycolate synthesis supports particularly useful as support reagents for the direct synthesis of 3'-labeled polynucleotides. Generally, the compounds of the invention have the structure (see fig. I) where T is an acid-cleavable hydroxyl protecting group, e.g., 4,4'-dimethoxytrityl; L1 is a linker for connecting a 3'-terminal nitrogen to carbon; L2 and L3 are linkers for connecting oxygen and carbon; W is a solid support, e.g., CPG or polystyrene; L4 is a linker for connecting the solid support to nitrogen; R1 and R2 are nitrogen substituents, e.g., hydrogen, lower alkyl, nitrogen protecting group, or label; and R3 through R7 are carbon substituents, e.g., hydrogen or lower alkyl. In a first particularly preferred embodiment, the synthesis supports of the invention are exemplified by compoundshaving the structure (see fig. II) where DMT is 4,4'-dimethoxytrityl and W is polystyrene. In a second particularlypreferred embodiment, the synthesis supports of the invention are exemplified bycompounds having the structure (see fig. III) where DMT and W are defined above. |
| priorityDate | 1996-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 91.