| abstract |
This invention provides compounds having the structure wherein R and R4 are each, independently, hydrogen, -CN, -OR2, -COR2, -COOR2, -CONR2R3, alkyl, alkenyl, alkynyl, perhaloalkyl, or halogen; the dashed line indicates an optional double bond; R1 is hydrogen, -OH, -OR2, or is absent when the double is present; R2 and R3 are each, independently, alkyl, alkenyl, alkynyl, phenyl, or phenylalkyl; R5 is hydrogen, alkyl of 1-6 carbon atoms, or -COR6. R6 is alkyl, alkenyl, alkynyl, cycloalkyl, phenylalkyl, or Ar; and Ar is an aryl or heteroaryl radical which may be optionally substituted or a pharmaceutically acceptable salt thereof that are useful as antipsychotic, antidepressant and anxiolytic agents useful in the treatment and relief of the symptoms of these disease states. |