http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2192754-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2262dd1649f7cd88ee89c4d6fc68c39d |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-13 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70567 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705 |
| filingDate | 1996-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a75ce6241ecf9ad6899b94b8ea5e166b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_996d97e406864c8aaee605830e9b56de |
| publicationDate | 1998-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2192754-A1 |
| titleOfInvention | Nur-re a response element which binds dimers of nur nuclear receptors and method of use therefor |
| abstract | The present invention relates to intracellular receptors, and methods for the modulation of transcription using same. More particularly, the invention relates to the Nur family of nuclear receptors. In general aspects, the present invention relates to the identification of a physiologically relevant response element (RE) for Nur family members, an ER-10 element, as well as to the demonstration that dimers specifically interact with the ER-10 to modulate transcription at physiologically relevant sites. The invention further relates to methods for modulating processes mediated by such nuclear receptors. In addition, the invention relates to oligonucleotide sequences that bind regulatory proteins that affect transcription, such as the Nur family of nuclear receptors, to DNA constructs comprising the oligonucleotide sequences, cells transfected with the DNA constructs, to methods of using same to provide for the controlled expression of heterologous genes, and for the the detection and recovery of new regulatory proteins. The present invention further provides bioassays for the identification of compounds as potential agonists or antagonists of transcription by the Nur family of nuclear receptors. Moreover, the invention relates to the dissection of protein-protein interactions or ligand-protein interactions involved in the modulation of transcription by the Nur family of nuclear receptors. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110521617-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110521617-A |
| priorityDate | 1996-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 101.