http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2190509-C
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bcff13f8573db698307f919e6385d5c4 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S516-93 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S516-923 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1275 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1075 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-1806 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0461 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-1217 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0438 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-14 |
| filingDate | 1995-05-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2008-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ca523f7d8e5b767f93d31f20ad2671aa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2f7eb37b09e951b60a2c5d59e6c0d2ef http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ba2d163d3261a54c1eb1e823d7a0c7cf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_532f073283eb726caf582d174e543773 |
| publicationDate | 2008-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2190509-C |
| titleOfInvention | Hepatocyte-selective oil-in-water emulsion |
| abstract | A heat and shelf-stable oil-in-water emulsion useful as a tissue or cell- selective delivery vehicle. Radioactive or stable, synthetic or semi-synthet ic polyhalogenated triglycerides, such as 2-oleoylglycerol-1,3-bis[7-(3-amino- 2,4,6-triiodophenyl)heptanoate] or 2-oleoylglycerol-1,3-bis[.omega.-(3,5-bis - trifluoromethyl)-heptanoate] or phenyl acetate, can be incorporated into the lipophilic core of a lipoprotein-like emulsion particle. The lipophilic core is surrounded by a phospholipid membrane comprising cholesterol and apolipoproteins. For hepatocyte-selective delivery, the emulsion is chylomicron remnant-like by being in a size range of 50 to 200 nm as measure d by number weighting analysis with a narrow size distribution ( 2 % greater than 300 nm) and having a composition simulating naturally-occurring chylomicron remnants. Use of cholesterol in the emulsion formula facilitates association of apolipoproteins, especially Apo E which are recognized by liv er cells and necessary for binding and uptake. Stability and size constraints c an be achieved by ultra high energy mixing equipment, such as the MicroFluidize r (Microfluidics Corp., Newton, MA) to form the emulsion. In preferred embodiments, osmolality of the emulsion is controlled by glycerol rather tha n normal saline. |
| priorityDate | 1994-05-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 226.