http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2186528-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_905824d9c333b0fe3cf112d52c78ef96 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-5156 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2833 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-001 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-34 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-34 |
| filingDate | 1995-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b1835d477fca473a45777d5b953019f7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6a32e8216b3afe4facbd495a36010520 |
| publicationDate | 1995-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2186528-A1 |
| titleOfInvention | Genetically modified cells for use in transplantation |
| abstract | Cells suitable for transplantation which can be used to deliver a gene product to an allogeneic or xenogeneic subject are disclosed. Such cells are modified to express a gene product and have at least one antigen on the cell surface which stimulates an immune response against the cell in an allogeneic or xenogeneic subject. Prior to administration of the modified cells, the antigen on the cell surface, such as an MHC class I antigen, is altered to inhibit rejection of the cell by an allogeneic or xenogeneic subject. Preferably, the antigen is altered by contact with an antibody, or fragment or derivative thereof, such as an F(ab)'2 fragment. Alteration of the antigen on the surface of the cells prior to administration inhibits immunological rejection of the cells and avoids the need for systemic immunosuppression of a subject. |
| priorityDate | 1994-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 421.