http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2183573-A1
Outgoing Links
Predicate | Object |
---|---|
assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_15d42f684941d5b0617ca7764ebdff07 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-96 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-96 |
filingDate | 1995-02-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cbe754ea66b4055af3b9ffa7901575b7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8093ee5251d2de72fae7b67316abac44 |
publicationDate | 1995-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | CA-2183573-A1 |
titleOfInvention | Isoenzyme calibrator/control products |
abstract | The invention relates to buffers used to stabilize isoenzymes with formulations which upon drying and reconstitution recover essentially all of the isoenzyme activity and immunological mass for long term shelf-life storage without experiencing dissociation and rearrangement of its subunits. The buffer used for the long term dry storage of an isoenzyme is a serum-free and a salt-free aqueous buffer which comprises: 1) a glass-forming sugar; 2) an antioxidant mixture; 3) a pH buffer; and 4) a non-ionic surfactant and/or a synthetic polymer and/or a gelatin. The buffer used for the reconstitution of a serum-free and salt-free isoenzyme sample comprises an aqueous buffer containing a salt. In addition, a serum-isoenzyme is disclosed which comprises: 1) a pH buffer; 2) a salt; 3) an antioxidant mixture; and 4) a non-ionic surfactant and/or a synthetic polymer and/or a gelatin. The figure shows the accelerated stability of isoenzyme mass in a serum-based and a serum-free aqueous buffer as determined by an arrhenius plot of the days to reach stability failure against the reciprocal of temperature, extrapolating a storage shelf-life at 5 .degree.C. |
priorityDate | 1994-02-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 575.