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filingDate 1995-02-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a48495ec7b6ded6d7644643137bf7b4b
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publicationDate 1995-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CA-2181367-A1
titleOfInvention Novel opioid peptides for the treatment of pain and use thereof
abstract This invention relates to a series of novel opioid peptides for the treatment of pain and pharmaceutically acceptable compositions comprising those peptides. The invention also teaches methods for controlling pain in patients using compositions of the invention. The peptides of this invention have a high degree of selectivity for the .mu.-opioid receptor. These peptides are highly lipophilic. In spite of their lipophilic character they do not readily cross the blood brain barrier (BBB). The peptides of the present invention are particularly well-suited as analgesic agents acting substantially on peripheral .mu.-opioid receptors. Because these peptides act peripherally, they substantially avoid producing side effects normally associated with central analgesic action.
priorityDate 1994-02-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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