| abstract |
The present invention relates to humanized antibodies and bind-ing proteins thereof, capable of binding to T cells exhibiting particular variable beta chains, and particularly those subpopulations expressing human V.beta. 5.2 and/or 5.3 and V.beta. 8.1. The present invention also relates to the preparation of such antibodies, to pharmaceutical compo-sitions containing them, and therapeutic utilization of the antibodies, specifically in autoimmune diseases. |