| abstract |
Compound of general formula (I) where R represents a hydrogen atom, an aliphatic, cycloaliphatic, araliphatic or aryl organic group, or an acyl group comprising such an organic group linked to the nitrogen atom by way of a carbonyl group; R1 and R2 are each selected from lower alkyl and cycloalkyl groups or together with the carbon atom to which they are attached form a lower cycloalkyl group; R3 represents a methyl group having .alpha.- or .beta.-configuration; Y represents a lower alkylene, alkenylene or alkynylene group optionally substituted by a hydroxyl, etherified hydroxyl or esterified hydroxyl group; and A= represents a cyclohexylidene moiety characteristic of the A-ring of a 1.alpha.-hydroxylated vitamin D or analogue thereof. Active compounds of the invention exhibit cell modulating activity and in certain cases may also have an effect on calcium metabolism. |