| abstract |
The present invention relates to the interplay between the level of DNA methyltransferase and demethylase activities, to the role of the interplay between these levels on the proliferative differentiated, tumoriganic and homeostatic state of the cell, and to the DNA methyltransferase and demethylase as therapeutic targets. The invention further relates to a redution of the level of DNA methylation through inhibitors and antagonist in ordar to inhibit the excessive activity or hypermethylation of DNA MeTase in cancer cells to induce the original cellular tumor suppressing program, to turn on alternative gene expression programs, to provide therapeutics directed at a nodal point of regulation of genetic information, and to modulate the genral level of methylase and demethylase enzymatic activity of a cell to permit specific changes in the methylation pattern of a cell. |