| abstract |
The inventive process for the preparation of a liposomal, in water dispersive, orally administerable, solid, dry therapeutic formulation, is characterized in that - in a first step at least one biological ac-tive, lipophilic active component, at least one lipid, which forms vesicles, and at least one component, which stabilizes the vesicle structure and/or serves as solu-bilizer, are dissolved in at least one organic solvent, then - in a second step from the obtained homoge-neous solution the organic solvent(s) is (are) removed, then - in a third step the so obtained homogeneous mixture is hydrated, then - in a fourth step the so obtained suspension is treated mechanically during such a long time, until said active component is contained completely and homo-geneous distributed in the formed liposomal particles, then - in a fifth step the water is removed by means of spray drying or by means of a granulating pro-cess and the so obtained solid, which has the form of a powder or of granules, is obtained. |