| abstract |
The present invention is concerned with compounds of formula (I), the pharmaceuticaliy acceptable acid addition salts thereof, and the stereochemically isomeric forms thereof, wherein R1 is hydrogen or C1-6alkyl; R2 is hydrogen or C1-6alkyl; R3 is hydrogen or C1-6alkyl; R4 is hydrogen, halo, C1-6alkyl, hydroxy, C1-5alkyloxy, aryloxy or arylmethoxy; R5 and R6 designate R5a and R6a, wherein R5a and R6a taken together form a bivalent radical; or R5 and R6 can designate R5b and R6b, wherein R5b is hydrogen and R6b is a heterocycle or an optionally substitued alkenyl or alkynyl group; or R5 and R6 designate R5c and R6c, wherein R5c and R6c are hydrogen, halo, C1-6alkyl, C3-6alkenyl; C3-6alkynyl, hydroxy, C1-6alkyloxy, cyano, aminoC1-6alkyl, carboxyl, C1-6alkyloxycarbonyl, nitro, amino, aminocarbonyl, C1-6alkylcarbonylamino, or mono-di(C1-6alkyl)amino; Q is a heterocyclic ring containing at least one nitrogen atom or a radical of formula (aa), pharmaceutical compositions, preparations and use as a medicine are also described. |