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filingDate 1994-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2002-01-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2aed303b1fb6c0b75bcf6f9b53244645
publicationDate 2002-01-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CA-2166198-C
titleOfInvention Regulation of site-specific recombination by site-specific recombinase/nuclear receptor fusion proteins
abstract An invention is described that permits the regulation of recombination in ce lls, organisms or appropriate cell-free systems. The invention involves creating fusion proteins between recombinase proteins, or components of recombinase systems, and ligand binding domains derived from nuclear receptors. The fusion proteins show little reco mbinase activity in the absence of the ligand that binds to the ligand binding domain. Upon binding of the ligand, recombinase activity is i nduced. The invention provides a practical means to regu late recobination in cells and organisms and, by linking ligand binding to recomb ination, provides a simple means whereby ligand binding can be measured as recombination achieved.
priorityDate 1993-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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