| abstract |
The invention relates generally to compositions of and methods for obtain-ing and using a polypeptide other than BCL-2 (SEQ ID NO.5) that affects pro-grammed vertebrate cell death. The in-vention relates as well to polynucleotides encoding those polypeptides, recombi-nant vectors carrying those sequences, the recombinant host cells including ei-ther the sequences or vectors, and re-combinant polypeptides. The invention further provides methods for using the isolated, recombinant polypeptides in as says designed to select and improve sub-stances capable of altering programmed cell death for use in diagnostic, drug de-sign and therapeutic applications. |