http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2163950-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a2fb784feb0deee31fdf1cd0665485b8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-74 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-64 |
| filingDate | 1995-11-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_de7128217efa1bd843323d5faef6cafd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0db7bed1befa0473d7285ec22ff19839 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7acf7e52d7bab511ca3d2d7bdc8b7378 |
| publicationDate | 1996-05-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2163950-A1 |
| titleOfInvention | 2-substituted benzothiazole derivatives and prophylactic and therapeutic agents for the treatment of diabetic complications |
| abstract | Unique benzothiazole derivatives which exert superior aldose redactase inhibiting actions are unexpectedly and advantageously useful in the prophylactic and therapeutic treatment of diabetic complications. A benzothiazole derivative compound of the formula (1): (1) wherein X is halogen, R1 and R2, which are the same or different, are each independently hydrogen or halogen, A is a methylene group or a sulfur atom, and -B-COOR3 is a group selected from the group consisting of (2) to (5): (2) (3) --(CH2)m--COOR3 (4) (5) wherein R3 is hydrogen or C1 to C3 lower alkyl, Y is hydrogen, halogen, C1 to C3 lower alkyl, carboxyl or dilower alkylamino and n is an integer of 1 to 3; Z is oxygen or sulfur, R4 is C1 to C3 lower alkyl, optionally substituted phenyl, optionally substituted benzyl or optionally substituted phenethyl and m is an integer of 2 to 5; or a pharmaceutically acceptable salt and a pharmaceutical composition comprising the same which is a useful prophylactic or therapeutic agent for the treatment of diabetic complications. |
| priorityDate | 1994-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 398.