http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2158968-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5dd0c561982c0ee0f2d981a737dc3039 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-341 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 1994-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ed1d7f590d7831797ade48bda722f427 |
| publicationDate | 1994-10-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2158968-A1 |
| titleOfInvention | (3-ketotetrahydrofuran-2-yl)ethanal derivatives and a method for their preparation |
| abstract | Compounds having utility in medicine in countering cellular malfunc-tion e.g. in conditions embraced by the general term "cancer", which com-pounds normally exist as a keto-enol tautomeric pair, the racemic keto form of which is represented by formula (Ia), wherein R is a hydrogen, lower alkyl, acyl, or another functional group of up to 6 carbons including at least one hetero atom, which atom may be directly bonded to the .beta.-carbon, which com-pound may be in the acyclic form shown or in a cyclic form as equilibrium keto-enol tautomer derivatives and anomeric forms thereof, including enan-tiomers when R is hydrogen and diastereoisomers when R is another group. A method of obtaining such a compound comprises selecting an appropriate dihydrofuran having a protected primary alcohol side chain in the 2-position, subjecting the said protected alcohol side chain-substituted dihydrofuran to oxidation using a chromium-based reagent to yield the corresponding acid, subjecting said acid to iodolactonisation conditions to yield the cis,cis,trans-trisubstituted iodo-lactone which upon displacement of the iodine provides the cis,cis,cis-tri-substituted hydroxylactone which is capable of being reduced to obtain a lactol which is in equilibrium with the corresponding open chain aldehyde. |
| priorityDate | 1993-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 56.