http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2158863-C
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_53dff29241864c5dc0eeca3fcbe40674 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F7-1804 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D205-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D305-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D407-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-695 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D205-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D305-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F7-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D407-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F7-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F7-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-14 |
| filingDate | 1994-03-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2006-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f0c142c90b4c3d2847d5d073abbc8903 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fef532eed82fbb6b48917eb664a77145 |
| publicationDate | 2006-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2158863-C |
| titleOfInvention | Taxanes having a pyridyl substituted side-chain |
| abstract | Taxane derivatives having a pyridyl substituted C13 side- chain. The derivatives are of the formula: <IMG> wherein X1 is -OX6, -SX7, or -NX8X9; X2 is hydrogen, C1-15 alkyl, C1-15 alkenyl, C1-15 alkynyl, C6-15 aryl, or C6-15 heteroaryl; X3 is hydrogen; X4 is pyridyl; X5 is -COX10, or -SO2X11; X6 is hydrogen, C1-15 alkyl, C2-15 alkenyl, C2-15 alkynyl, C6-is aryl, C6-15 heteroaryl, or a hydroxy protecting group; X7 is C1-15 alkyl, C2-15 alkenyl, C2-15 alkynyl, C6-15 aryl, C6-15 heteroaryl, or sulfhydryl protecting group; X8 is hydrogen, C1-15 alkyl, C2-15 alkenyl, C2-15 alkynyl, C6-15 aryl, C6-15 heteroaryl, or heterosubstituted C1-15 alkyl, C2-15 alkenyl, C2-15 alkynyl, C6-15 aryl or C6-15 heteroaryl; X9 is an amino protecting group; X10 is C1-15 alkyl, C2-15 alkenyl, C2-15 alkynyl, C6-15 aryl, C6-15 heteroaryl, t-butoxy, or heterosubstituted C1-15 alkyl, C2-15 alkenyl, C2-15 alkynyl, C6-15 aryl or C6-15 heteroaryl; X11 is C1-15 alkyl, C2-15 alkenyl, C2-15 alkynyl, C6-15 aryl, C6-15 heteroaryl, -OX10 or -NX8X14: X14 is hydrogen, C1-15 alkyl, C2-15 alkenyl, C2-15 alkynyl, C6-is aryl, or C6-15 heteroaryl; R1 is hydrogen, hydroxy, protected hydroxy or together with R14 forms a carbonate; R2 is hydrogen, hydroxy, -OCOR31 or together with R2a forms an oxo; R2a is hydrogen or taken together with R2 forms an oxo or; R4 is hydrogen, together with R4a forms an oxo, oxirane or methylene, or together with R5a and the carbon atoms to which they are attached form an oxetane ring; R4a is hydrogen, C1-15 alkyl, C2-15 alkenyl, C2-15 alkynyl, C6-15 aryl, C6-15 heteroaryl, cyano, hydroxy, -OCOR30, or together with R4 forms an oxo, oxirane or methylene; R5 is hydrogen or together with R5a forms an oxo; R5a is hydrogen, hydroxy, protected hydroxy, acyloxy, together with R5 forms an oxo, or together with R4 and the carbon atoms to which they are attached form an oxetane ring; R6 is hydrogen, C1-15 alkyl, C2-15 alkenyl, C2-15 alkynyl, C6-15 aryl, or C6-15 heteroaryl, hydroxy, protected hydroxy or together with R6a forms an oxo; R6a is hydrogen, C1-15 alkyl, C2-15 alkenyl, C2-15 alkynyl, C6-is aryl, or C6-is heteroaryl, hydroxy, protected hydroxy or together with R6 forms an oxo; R7 is hydrogen or together with R7a forms an oxo; R7a is halogen, hydroxy, or together with R7 forms an oxo; R9 together with R9a forms an oxo; R10 is hydrogen: R10a is -OCOR29, hydroxy, or protected hydroxy; R14 is hydrogen, C1-15 alkyl, C2-15 alkenyl, C2-15 alkynyl, C6-is aryl, Cg-15 heteroaryl, hydroxy, protected hydroxy or together with R1 forms a carbonate: R14a is hydrogen, C1-15 alkyl, C2-15 alkenyl, C2-15 alkynyl, C6-15 aryl, or C6-15 heteroaryl; R29 and R30, are independently hydrogen, C1-15 alkyl, C1-15 alkenyl, C1-15 alkynyl, monocyclic C6-15 aryl or monocyclic C6-is heteroaryl; and R31 is hydrogen, C1-15 alkyl, C2-15 alkenyl, C2-15 alkynyl, phenyl or monocyclic C6-15 heteroaryl. The derivates are useful as antitumor and antileukemia agents. |
| priorityDate | 1993-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 136.