| abstract |
Provided are conjugates useful in cancer, cardiovascular or infectious disea se detection and/or therapy. The conjugate is of a ligan d and protein. The ligand has a moiety capable of binding to mercapto groups a nd is capable of chelating a metal useful for detection or therapy. The protein reacts with a substance associated with a targeted cell , pathologic lesion or pathogen. The protein prior to co njugation has at least one mercapto group which becomes a site for conjugation to the ligand. Also provided are metal chelates of the conjugat e, methods of detection and therapy, methods for producing the conjugate and ph armaceutical compositions of the conjugates. |