http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2154203-A1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-0205 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-02 |
| filingDate | 1995-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fb144a3c6a8078602614c2d308a5976c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_94a7694fb1a6c4a5d2bfe7f698014612 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_417cae668e8f231064dc8a1264cb768e |
| publicationDate | 1996-02-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2154203-A1 |
| titleOfInvention | Pentapeptide methyl esters |
| abstract | Herein disclosed are several pentapeptide methyl ester derivatives of dolastatin 10, using both naturally occurring and modified amino acids. The selected modified amino acids are constituents of dolastatin 10 which is a structurally distinct peptide with excellent in vitro and in vivo antineoplastic activity. The structures of these compounds are as shown below: 10a) R1 = i- Pr ; R = -NH(Me)2 ; R2 = -CH2CH2CH2NH-cbz 10b) R1 = i-Pr ; R = -NH(Me)2 ; R2 = 11a) R1 = -(CH2)4NH-cbz ; R = -NH(cbz) ; R2 = 11b) R1 = ; R = -NH(cbz) ; R2 = -CH2CH2CH2NH-cbz 11c) R1 = ; R = -NH(cbz) ; R2 = -CH2-S-Me |
| priorityDate | 1994-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 36.