| abstract |
Compounds of formula (I) as well as methods for their preparation, their pharma-ceutical preparations and their use. The com-pounds of formula (I) are useful in therapy, especially as analgesics and as immunosup-pressive agents. R3, R4, R5, R6 are all H or R4 and R5 are both H and R3 and R6 are both lower alkyl groups or R3, R5, R6 are all H and R4 is F, Cl, Br, OH, NH2 or NO2; R7 is C?O or CH2; R8 is H or a lower alkyl group; R9 is (II), wherein m is 0-2 or (III) or (IV) or (V) or (VI) or (VII) or (VIII) wherein R10 is H, F, Cl, Br or I and m is 0-2; R11 is OH, NH2 or (IX) wherein R12 is H, NO2, F, Cl, Br or I, m is 0-2, R13 is COOH, CONH2, CH2OH, or any additional amino acid or pep-tide segment, or R11 is (X) wherein R14 is COOH, CONH2, CH2OH, or any additional amino acid or peptide segment; with the ex-ceptions of the compounds wherein R1, R2, R3, R4, R5, R6 and R8 are all H, R7 is C?O and R9 is (XI) and R11 is Phe-OH, Phe-NH2, OH or NH2. |