| abstract |
Fused benzo compounds of formula (I), wherein A is a 2 to 6 membered hydrocarbon spacer group, B is a polar divalent group selected from SO, SO2, and a group (a); U is C, N or CH; X is a divalent 3-4 membered chain optionally comprising one or more heteroatoms; R1 is an alipathic hydrocarbon group, arylalkyl or diphenylalkyl; R2 and R3 are hydrogen or alkyl or together form an ethylene or propylene bridge; R4, R5, and R6 are hydrogen or substituents: R7 and R8 are hydrogen or substituents including, a group -COOR9 and a group -CONR10R11: are 5-HT1A receptor ligands useful in the treatment of CNS disorders. Pharmaceutical compositions comprising the compounds and their use for the manufacture of a pharmaceutical preparation are also disclosed. |