| abstract |
Antiallergic triazolo(pyrrolo, thieno or furano)azepines of formula (I), the pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof, wherein each of the dotted lines independently represents an optional bond; -E-G- is a bivalent radical of formula -X-C(R1) CH-(a-1); or -CH C(R2)-X- (a-2); X represents O, S or NR3; R3 represents hydrogen, C1-6alkyl or C1-4alkylcarbonyl; -B D- is a bivalent radical of formula -C(R4) N- (b-1); or -N C(R5)- (b-2); L represents hydrogen; C1-6alkyl; substituted C1-6alkyl; C3-6alkenyl; C3-6alkenyl substituted with aryl; or, L represents a radical of formula -Alk-Y-Het1 (c-1), -Alk-NH-CO-Het2 (c-2) or -Alk-Het3 (c-3). Compositions comprising said compounds, processes of preparing the same and intermediates in the preparation thereof. |