| abstract |
A description is given of perfluoroalkyl-substituted benzoylguanidines of the formula I (see formula I) where R(1) is (C1-C6) -perfluoroalkyl-SO m; R(2) and R(3) are H, halogen, alk(yl)oxy), phenoxy; R(4) and R(5) are H, alkyl, Hal, CN, OR(7), NR(8)R(9), -(CH2)n-(CF2)o-CF3 and of the pharmacologically acceptable salts thereof; the compounds I are obtained by reacting a compound II (see formula II) with guanidine, L being a leaving group which is able readily to undergo nucleophilic substitution. |