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filingDate 1993-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 1999-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 1999-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CA-2148823-C
titleOfInvention Sustained release microsphere preparation containing antipsychotic drug and production process thereof
abstract A sustained release microsphere preparation which is produced by including a hydrophobic antipsychotic drug such as bromperidol, haloperidol or the like into a base composed of a high molecular weight polymer having in vivo histocompatibility such as polylactic acid, poly(lactic-co-glycolic)acid or the like, and a process for the production thereof. When a long-term administration is required, desired pharmacological effects can be obtained by one injection per 1 to 8 weeks, in stead of daily administration. As the result, considerable improvement in compliance at the time of maintenance therapy can be expected. Also, since a high molecular weight polymer having in vivo histocompatibility is used, surgical operations such as embedding and the like are not required at all, and subcutaneous and intramuscular administrations can be made easily absolutely in the same manner as the case of conventional suspension injections so that recovery of the material is not required. In addition, resistance and pain at the time of administration are small.
priorityDate 1992-11-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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