| abstract |
A phosphonic diester derivative represented by general formula (1), (see formula I) wherein R1, R2 and R3 are the same or different from one another and each represents hydrogen, lower alkyl, halogeno, cyano, hydroxy or lower alkoxy which may be substituted by halogen, phenyl or hydroxypiperidino; R4 represents hydrogen, lower alkoxy, halogeno or lower alkyl which may be substituted by halogeno or cyano; and R5 and R6 are the same or different from each other and each represents hydrogen or lower alkyl. This derivative is excellent in hypolipemic, hypotensive, hypoglycemic effects and is useful for treating and preventing hyperlipemia, hypertension and diabetes. |