| abstract |
Heterocyclic amines of the formula: Ar-X-A-NR1R2 wherein Ar is a bicyclic or tricyclic aromatic group which is unsub-stituted or which bears one or more substituents selected from halo, nitro and cyano groups and alkyl and alkoxy groups each of up to 4 carbon atoms; wherein X is a direct link or is -O-, -S-, -SO- or -SO2- or has the formula -C(R3) = CH- wher-ein R3 is hydrogen or alkyl of up to 4 carbon atoms; wherein A is straight or branched alkylene or alkenylene of 3 to 8 car-bon atoms which may be interrupted by -O-, -S- or -NH-; and wherein NR1R2 is a cyclic amino group; or a pharmaceutical-ly acceptable acid addition salt thereof, are of value for therapeutic use, particularly in the treatment of myocardial ischaemia and hypertension and in the treatment of fungal infections. |