| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_01a96e8bbea00eeaa0b50c2a0c000dba
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8f3507d0f848de9170739f6af3c5554c |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-156 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6897
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-566
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate |
1993-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b5099e9f345d634a55283e1667d513df
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cf0b74f91d3df6a0069270f89841a193
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2f8d95690684069267da331e7e3ef114
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f2ca5944ae56a25f356a30acc58a61cc |
| publicationDate |
1994-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CA-2144768-A1 |
| titleOfInvention |
Functional assay for tumor supressor genes |
| abstract |
A method for determining whether an individual, i.e., a human, carries a mutation which encodes a polypeptide which is a transcriptional regulator including the steps of obtaining a first nucleic acid comprising cDNA encoding both alleles of the gene from a cell sample from the individual, providing a second nucleic acid comprising a binding site operably linked to DNA encod-ing a detectable protein such that transcription of the DNA encoding the detectable protein is regulated by interaction of the tu-mor suppressor polypeptide with the binding site, transfecting these first and second nucleic acids into cells with low levels of the tumor suppressor polypeptide, and then examining the transfected cells for the level of the detectable protein, the level being correlated with the presence of a mutation in at least one of the alleles of the gene. |
| priorityDate |
1992-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |