http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2144048-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_07b71571160c289fbf5fc680dfea513f |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D493-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate | 1993-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_daef81885debc423fb62ac89bde21229 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ab89e8dff96be90808fc4e53539fbd30 |
| publicationDate | 1994-03-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2144048-A1 |
| titleOfInvention | PROCESS FOR PREPARING CERTAIN PYRROLO[3,4- .BETA.]QUINOLINES, CERTAIN 1H-PYRANO[3',4':6,7]INDOLIZINO[1,2-ß]QUINOLIN-3, 14(4H,12H)-DIONES, AND CERTAIN 8-METHYL-7-(OXOPROPYL)- INDOLIZINO[1,2-ß]QUINOLIN-9(11H)-ONE S |
| abstract | The present invention provides a process for preparing certain pyrrolo[3,4-b]quinolines, certain 1H-pyrano[3',4':6,7]indo-lizino[1,2-b]quinolin-3,14(4H,12H)-diones, specifically camptothecin and its analogs, and certain 8-methyl-7-(oxopropyl)-indoliz-ino[1,2-b]quinolin-9(11H)-ones, specifically mappicine ketones and mappicines, said process comprising the step of intramolecu-lar [4 + 2] cycloaddition of the N-arylimidate portion of a compound of formula (IV) where: X = OH, OAlCl2, Cl, Br, I, F, OR, OSO2CF3 or any good leaving group or H; R1 = H, or OR, where R is an ester protecting group; R2 = H, NO2, or a protect-ed amine function; R3 = H, C2H5, or a trialkylsilyl; R4 = H or CH2COOEt; R5 = COOMe or tosyl; or R4 and R5 are joined together to form a substituted pyridone (IVa): Y= H or Y,R1 = -OCH2O-, formula in which A = H,COOR, or a functionnali-ty for preparation of the hydroxymethyl (C-17) portion of an E ring lactone; B = H, OH, an appropriate leaving group such as halide or O(trifluoromethanesulfonate) or a functionality for preparation of C-(18-21) of the E ring lactone portion of camptothecin, with the unactivated acetylene portion of said compound. |
| priorityDate | 1992-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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