| abstract |
Compositions and methods are provided for the treatment and diagnosis of diseases amenable to treatment through modu-lation of the synthesis or metabolism of intercellular adhesion molecules. In accordance with preferred embodiments, oligonucle-otides are provided which are specifically hybridizable with nucleic acids encoding intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and endothelial leukocyte adhesion molecule-1. The oligonucleotide comprises nucleotide units suffi-cient in identity and number to effect said specific hybridization. In other preferred embodiments, the oligonucleotides are specif-ically hybridizable with a transcription initiation site, a translation initiation site, 5'-untranslated sequences, 3'-untranslated se-quences, and intervening sequences. Methods of treating animals suffering from disease amenable to therapeutic intervention by modulating cell adhesion proteins with an oligonucleotide specifically hybridizable with RNA or DNA corresponding to one of the foregoing proteins are disclosed. Methods for treatment of diseases responding to modulation cell adhesion molecules are dis-closed. |