http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2143519-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D513-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D507-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-435 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D513-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-535 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D513-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D463-16 |
| filingDate | 1995-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_27a45fc27833fc3aa95f1e00a50a75c4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_033f175937882d6b6bacfb34695a95bb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8f97765d8c0c40bdbd18a7e9e7a6dd7e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f02eadb7dd685b522cf7ff0db7298fa9 |
| publicationDate | 1995-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2143519-A1 |
| titleOfInvention | Beta-lactams |
| abstract | .beta.-Lactams are described, namely of the general formula I in which Z signifies methylene, oxygen or sulphur and R signifies hydrogen, lower (cyclo)alkyl optionally sub-stituted by carboxy, lower alkoxycarbonyl, carbamoyl, lower alkylcarbamoyl, phenylcarbamoyl or hydroxyphenyl-carbamoyl, lower alkenylmethyl, lower alkenylmethoxy-carbonyl, formyl, lower (cyclo)alkanoyl or (cyclo)alkyl-sulphonyl optionally substituted by halogen, cyano, carbamoyl-lower-alkoxy, carbamoyl-lower alkylthio or carbamoyl-lower alkylamino, carbamoyl optionally substituted by lower (cyclo)alkyl, lower alkoxycarbonyl-lower alkyl, benzyloxycarbonyl-lower alkyl or carboxy-lower alkyl or a ring structure of the general formulae Q-X-CO- (a1) Q-X-SO2- (a2) wherein Q represents a 5- or 6-membered ring optionally containing nitrogen, sulphur and/or oxygen and X represents a direct bond or one of the groups -CH2-, -CH2CH2-, -CH=CH-, -NH-, -NHCH2-, -CH2NH-, -CH(NH2)-, -CH2CH2NH-, -C(=NOCH3)-, -OCH2- and -SCH2-; and wherein further A signifies lower alkyl, hydroxy-lower alkyl, vinyl, cyano-vinyl, lower alkoxy, optionally phenyl-substituted lower (cyclo)alkanoyloxy or (cyclo)alkylsulphonyloxy, optionally lower-(cyclo)alkyl-substituted benzoyloxy or phenyl-sulphonyloxy, a residue -S-Het or -S-CH2-Het, wherein Het represents a 5- or 6-membered heterocycle containing nitrogen, sulphur and/or oxygen, or a residue -CH2-L, wherein L represents optionally phenyl-substituted lower (cyclo)alkanoyloxy or (cyclo)alkylsulphonyloxy, optionally lower (cyclo)alkyl-substituted benzoyloxy or phenyl-sulphonyloxy, carbamoyloxy, lower (cyclo)alkoxycarbonyl, carboxy, azido, amino, lower (cyclo)alkanoylamino, lower (cyclo)alkylsulphonylamino, lower (cyclo)alkylamino, di-lower (cyclo)alkylamino, a 5- or 6-membered ring bonded to a nitrogen atom or a residue -S-Het or -S-CH2-Het, wherein Het has the above significance, and pharmaceutically compatible, readily hydrolyzable esters and salts of these compounds. A process for the manufacture of the .beta.-lactams described above as well as intermediates occurring therein are also described, as are corresponding medicaments. The products have .beta.-lactamase inhibiting properties and are useful in the control of .beta.-lactamase-forming pathogens in combination with .beta.-lactam antibiotics. They also exhibit antibacterial activity of their own and can accordingly be used themselves in the control of infectious diseases. |
| priorityDate | 1994-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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