| abstract |
Provided are new derivatives of neuraminic acid of formula (I), where Ac represents an aryl residue of an aliphatic, araliphatic aromatic, alicyclic, or heterocyclic carboxylic acid, including carboxylic amides, their 2-hydrocarbyl-glycosides, and their peracylated derivatives at the hydroxy groups of both these series of amides. These compounds are therapeutically useful in providing a protective effect against the neurotoxicity induced by excitatory amino acids, and can therefore be used in therapies of the central nervous system following cerebral degenerations or lesions, metabolic dysfunctions, aging, and toxic-infective and chronic neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's diseases. |