| abstract |
2141425 9405296 PCTABS00030 Described is a method of inhibiting the enzymatic metabolism of nitrogen substituted acridines comprising co-administering with the acridine an effective oxidase inhibiting amount of a P450 1A2 inhibitor. The oxidase is one whose activity is induced by beta-naphthaflavone, 3-methylcholanthrene, arochlor, 2,3,7,8-tetrachlorodibenzo-p-dioxin and isosafrole. The oxidase inhibitor may be a naphthyridine, a xanthine, a phenoxy amino alkane, a carbamoyl imidazole, a heterocyclic guanidine, a quinoline or a trifluoromethyl oxime ether. |