http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2137406-C
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1b275aebcfae1a839e38c899b7d8b665 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e9cd1139084959b8810545118d14a684 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d466cf45ab903557c6f1c8757827f5a7 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C213-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C217-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D303-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C215-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B53-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-08 |
| filingDate | 1994-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2005-09-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aaecae7d5326fd1fea4872e48e218114 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c1ec1b9496d267479a794aa4b46218e7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_095fc97b148f99fd598dfa590f19db86 |
| publicationDate | 2005-09-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2137406-C |
| titleOfInvention | Process for key intermediates for hiv protease inhibitors |
| abstract | Disclosed herein is a stereospecific synthesis amenable to the large scale preparation of a hydrochloric acid addition salt of a chlorohydrin of the formula (see formula I) wherein R1 and R2 are amino protective groups and R3 is an amino acid side chain or a protected amino acid side chain. The synthesis involves reacting an aldehyde of the formula wherein R1, R2 and R3 are as defined hereinbefore with (chloromethyl)lithium at -20 °C or below and contacting the resulting diastereoisomeric mixture of lithium alcoholates with aqueous hydrochloric acid to obtain a separable mixture of the hydrochloric acid addition salts of the chlorohydrin and its corresponding hydroxy diastereoisomer. The hydrochloric acid addition salt of the chlorohydrin is transformed readily into corresponding optionally amino-protected aminoepoxides; for example, 3(S)-(tert-butyloxycarbonylamino)-1,2(S)-epoxy-4-phenyl-butane. |
| priorityDate | 1994-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 78.