http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2136832-C
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S623-92 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S623-915 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2310-00365 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-507 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2-062 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-24 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61F2-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61F2-06 |
| filingDate | 1994-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2002-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d75d22ec7b447cce685ad1542341e3f6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6e48ce96a8be75d555822f85ddcf9f68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0b684ae313e5c082a9197d8bfbfa85d0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_21502bc25d74af6fbf8bfc5929f6e0bb |
| publicationDate | 2002-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2136832-C |
| titleOfInvention | Tissue equivalents |
| abstract | A method of forming a tissue equivalent is described. A length of polyester tube is threaded over a mandrel (H) and attached at either end by clips at A and D. A block (F) is then screwed into place. The polyest er is then pre-soaked by injecting through Tap (2) an acidified collagen solution for approximately one hour. After a suitable period of tim e the excess solution is aspirated off. Following this stage, a second, alkaline solution is injected into the apparatus which contains smooth muscle cells (SMC). Thus, neutralisation of the collagen impregnated within the fabric of the tube occurs leading to spontaneous fibrillogenesis within the interstices of the cloth, eliminating the risk of delamination. The apparatus is then incubated. The collagen contracts dow n onto the fabric tube and the cell-impregnated gel becomes incorporated into the presoaked collagen. The pre-impregnated collagen and t he collagen provided in the aqueous mixture contract down as one into a coherent whole with the SMC. The tissue equivalent is then lined with endothelial cells and the apparatus again incubated and fed at increasing intraluminal pressures applied either statically or dynamicall y. This is believed to cause the vessel to become preconditioned to the pressure it will work under as an implant. This allows organisation o f the basement membrane which in turn promotes EC attachment and theoretically prevents smooth muscle cell hyperplasia. |
| priorityDate | 1993-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 38.