| abstract |
The present invention relates to compositions comprising pharmaceuticallyacceptable carriers and a phosphonocarboxylate, or a pharmaceutically-acceptable salt thereof, having a structure according to formula (I), wherein (A) (1) A is selected from the group consisting of hydrogen; halogen ; SR1; R2SR1; amino; hydroxy; and substituted or unsubstituted C1-C8 alkyl; (2) B is (a) NH2; etc. or (B) A and B are covalently linked together with C* to form a monocyclic or bicyclic ring having structure .alpha.. The present invention further relates to novel phosphonocarboxylates and pharmaceutically-acceptable salts thereof. Finally, the present invention relates to methods for treating or preventing pathological conditions characterized by abnormal calcium and phosphate metabolism in humans or other mammals. This method comprises administering to a human or other mammal in need of such treatment of a safe and effective amount of a compound or composition of the present invention. |