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filingDate 1994-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2005-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c3bf8277249b012830d21d12da3f2033
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publicationDate 2005-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CA-2133144-C
titleOfInvention Vitamin d3-analogs
abstract The invention relates to the compounds 1,25-dihydroxy-16-ene-24-oxo-cholecalciferol and 1,24,25-trihydroxy-16-ene-cholecalciferol which stimulate differentiation of HL-60 cells, rendering them useful as an agent for the treatment of neoplastic diseases such as leukemia, and also decrease proliferation of human keratinocytes, rendering them useful as an agent for the treatment of hyperproliferative disorders of the skin such as psoriasis. They are prepared by perfusing 1,25-dihydroxy-16-ene-cholecalciferol in rate kidneys, extracting the perfusate and isolating 1,25-dihydroxy-16-ene-24-oxo-cholecalciferol and 1,24,25-trihydroxy-16-ene-cholecalciferol.
priorityDate 1993-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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