| abstract |
Disclosed herein are peptide derivatives of the formula A-B-D-CH2CH¢CH2C(O)R1!C(O)-NHCH¢CR2(R3)COOH!C(O)-E wherein A is a terminal group, for example an optionally substituted phenylalkanoyl; and B is an N-methyl amino acid residue; or A and B together form a saturated or unsaturated alkylamino-carbonyl; D is an amino acid residue; R1 is alkyl, cycloalkyl, a monosubstituted or a disubstituted amino; R2 is hydrogen or alkyl and R3 is alkyl; or R2 is hydrogen and R3 is phenylalkyl, or R2 and R3 are joined to form a cycloalkyl; and E is a terminal unit, for example, an alkylamino or a monovalent amino acid radical such as NHCH(alkyl)C(O)4H. The derivatives are useful for treating herpes infections. |