| abstract |
Novel 11-benzaldoxime-estra-diene derivatives of the general Formula I and their pharmaceutically-acceptable salts, processes for their production, and pharmaceutical composition containing such compounds, are provided herein. In such compounds of Formula I, Z is -CO-CH3, -CO-0-C2H5, -CO-NH-phenyl, -CO-NH-C2H5, -CO-C2H5, CH3, or -CO-phenyl. Such compounds of the general, Formula I are produced by the esterification or the urethane formation of a compound of the general Formula II with a compound of the general Formula II by the reaction of that compound with an esterifying, or an etherifying or an urethane-forming agent which contains the group Z, or its precursor. Such compounds show strong antigestagenic effects combined with reduced glucocorticoid activity. |