| abstract |
2130096 9321170 The present invention relates to compounds of formula (I), in which R represents (a) a hydrogen atom, (b) a radical alkyl, (c) an alkyl radical, (d) a phenyl radical, (e) a 2 or 3-pyridylalkyl radical, (f) a 2-quinolylalkyl radical, (g) a naphthylalkyl radical, (h) a cycloalkylalkyl radical, (i) a radical 2H-3-naphto [1,8-cd] isothiazol-2-yl-1,1-dioxide) alkyl, (j) a radical (5,6-dihydro 1H, 4H-1,2,5-thiadiazolo [4,3,2-ij] quinolyl-2,2-dioxide) alkyl, (k) a radical -alk-CO-R5, (l) a radical -alk-R6-R7, (m) a radical 4-phenylpiperazinylalkyl in which the phenyl ring is optionally substituted by one or more substituents chosen from halogen atoms and alkyl or alkoxy radicals, (n) a 10-phenothiazinylalkyl radical, (o) a (10-alkyl-2-phenothiazinyl) alkyl radical, (p) a radical 3-indolyalkyl, (q) a phenylalkyloxy radical, (r) a radical 1-phenylalkyl-4-piperidyle, (s) a 2-thienylalkyl radical or (t) a radical phenylalkyl in which the phenyl is unsubstituted or substituted by one or more substituents chosen from atoms halogen and alkyl, alkoxy, polyfluoroalkyl, amino, nitro, cyano, phenyl, vinyl, polyfluoroalkoxy, alkoxycarbonyl, carboxy, phenylalkyloxy, phenylalkyl, benzoylamino, phenylcarbonyl and phenoxy in which the phenyl nucleus is optionally substituted with one or more substituents chosen from atoms halogen and alkyl, alkoxy or polyfluoroalkyl radicals, R1 represents a carboxy, alkoxycarbonyl, tetrazolyl radical, -CO-NH2, -CO-NH-alk, -CO-N (alk) 2, -CO-NHOH, -CO-N (alk) OH, -CO-NH-O-R8, -CO-N (alk) -OR8 or a group convertible into carboxy radical in vivo, R2, R3 and R4, identical or different, each represents a hydrogen or halogen atom or an alkyl radical or alkoxy, R5 represents a hydroxy, alkoxy, phenyl radical, or -NR9R10, R6 represents an oxygen, sulfur atom or nitrogen or an SO, SO2 or -N-alk radical, R7 represents a alkyl, phenylalkyl or phenyl radical optionally substituted by one or more halogen atoms, R8 represents a radical alkyl or phenylalkyl, R9 and R10, identical or different, represent a hydrogen atom or an alkyl or phenyl radical and alk represents an alkyl or alkylene radical, their salts, their preparation and the medicines containing them. |