http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2129565-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5929f2d6f4dba84be8dd3a8ba633db12 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-70 |
| filingDate | 1994-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9268b7cc3c959d694be1485238cddb45 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6b2f6093bb1878fee6a9ca97618557c3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d8cda488a0c4ecb05edc5ae6542f6349 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4152c742f1d234e790fba05a06ec5867 |
| publicationDate | 1995-02-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2129565-A1 |
| titleOfInvention | Oligonucleotide compounds, their production and use |
| abstract | OLIGONUCLEOTIDE COMPOUNDS, THEIR PRODUCTION AND USE Abstract of the Disclosure An oligonucleotide compound or a salt thereof, which has a nucleotide sequence represented by formula (I): (I) wherein W represents hydrogen or a protective group; B1, B2 and B3 each represent nucleic acid residues, wherein each B2 may be the same or different when n is 2 or more; X1, X2 and X3 each represent OH, SH, C1-5 alkyl, C1-5 alkoxy, C1-5 monoalkylamino or an aromatic ring group which may be substituted or unsubstituted, wherein each X3 may be the same or different when n is 2 or more; R1, R2 and R3 each represent hydrogen, OH, halogen, C1-5 alkoxy or C1-5 alkoxyalkyloxy, wherein each R2 may be the same or different when n is 2 or more; and n represents an integer from 1 to 98 is disclosed. The oligonucleotides (I) of the present invention or the salts thereof can (1) inhibit expression of genes associated with the development of malignant tumors in malignant tumor cells, (2) inhibit expression of viral genes derived from viruses, (3) inhibit expression of genes producing proteins which contribute to the development of inflammations, (4) control expression of drug-resistant genes which cause complications in chemotherapy of malignant tumors, and (5) inhibit production of cell growth factors related to reangiostenosis after PCTA (percutaneous transluminal coronary angioplasty) by complementation to DNAs or mRNAs of genes inducing various diseases. They can be therefore used as antitumor agents, antiviral agents, antiinflammatory agents and drugs for controlling expression of specific genes such as resistance genes. These oligonucleotides can also be used as probes. Further, these oligonucleotides can be used in novel drug screening assays. |
| priorityDate | 1993-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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