| abstract |
ABSTRACT 2-AMINOPYRAZINE-5-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPEUTICS Compounds corresponding to the general formula (I) (I) in which n represents 0 or 1, R1 represents a methyl group, in which case R2 represents a phenoxy(C1-C4)alkyl group (in which the phenoxy group is optionally substituted), or else R1 and R2 together form, and with the nitrogen atom which carries them, a 4-(phenoxymethyl)piperid-1-yl group (in which the phenoxy group is optionally substituted) or a 4-phenylpiperazin-1-yl group (in which the phenyl group is optionally substituted), R3 represents a hydrogen atom or a methyl group, R4 represents a hydrogen atom and R5 represents a hydrogen atom or a group of general formula -CH2-CH2-NH-R6, R6 being a hydrogen atom or a tert-butyloxycarbonyl, 4-carbamoylpyrimidin-2-yl or 5-carbamoylpyrazin-2-yl group, are useful in the treatment of diseases and complaints involving hyperactivity of the .alpha.-adrenergic system at the level of the lower urinary apparatus. |