| abstract |
ABSTRACT OF THE DISCLOSURE The disclosure describes a pharmaceutical composition comprising an aromatase-inhibiting effective amount of a compound selected from the group consisting of compounds of the formula (I): (I) including their stereoisomers and salts thereof, wherein R1 is halogen or phenyl; m is 0, 1, 2 or 3; k and n each are independently 0, 1 or 2; R2 and R3 each are independently H or OH; R6 and R7 each are independently H or C1-4 alkyl; R8 and R9 each are H or R8 and R9 form -C(R4)(R5)-C(R11)(R12)- bond wherein R4, R5, R11 and R12 each are independently H or C1-4 alkyl; Y is N or CH; and R10 is H or halogen, or R10 combines with R2 to form -O-bond, with proviso that if R8 and R9 form -C(R4)(R5)-C(R11)(R12)- bond, R3, R6 and R7 each are H, and k and n each are 1, then R2 and R10 form -O- bond, and a pharmaceutically acceptable carrier or diluent. |