http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2116526-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2e3830f35387a1c32061dea3ee310851 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b21f650fc35b3e1947103e89adb06f3f |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-7051 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-564 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-725 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-02 |
| filingDate | 1992-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ed06da3f1e28b942769226c8b2c954bf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1833ee937d495e4ec46d5b3d402592c9 |
| publicationDate | 1993-03-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2116526-A1 |
| titleOfInvention | T cell receptor-based therapy for rheumatoid arthritis |
| abstract | There is provided by this invention a novel method of treating rheumatoid arthritis in a mammal. The method comprises the steps of obtaining a sample of synovium from the mammal; identifying in said sample T cell receptor variable regions; and administering to said mammal an effective amount of antibodies to at least one of said T cell receptor variable regions or antigenic fragments thereof. The invention further provides a novel method of treating rheumatoid arthritis in a mammal comprising the steps of administering to said mammal an effective amount of antibodies to mammalian T cell receptor variable regions selected from the group consisting of V.alpha.17, V.alpha.1, V.beta.12, V.beta.14, V.beta.17 and V.beta.7 and antigenic fragments thereof. The invention further comprises a novel method for immunizing a mammal to prevent the occurrence of rheumatoid arthritis or to treat ongoing rheumatoid arthritis. The method comprises the steps of administering to said mammal mammalian T cell receptor variable regions selected from the group consisting of V.alpha.17, V.alpha.1, V.beta.12, V.beta.14, V.beta.17, V.beta.7 and antigenic fragments thereof. Kits comprising mammalian T cell receptor variable regions selected from the group consisting of V.alpha.17, V.alpha.1, V.beta.12, V.beta.14, V.beta.17 and V.beta.7 and antigenic fragments thereof or antibodies to said variable regions are also provided by the invention. |
| priorityDate | 1991-08-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 189.