| abstract |
Compounds of formula (I), and salts and prodrugs thereof wherein n is 1, 2 or 3; X represents O or S; R1 represents optionally substituted phenyl; R2 represents aryl, heteroaryl, benzhydryl, or benzyl; R4 and R5 each independently represent H, halo, CH2OR9, C1-6alkyl, oxo, CO2R10 or CONR10R11; R8 represents H, COR9, CO2R10 or optionally substituted C1-6alkyl; R9 represents H, C1-6alkyl or phenyl; and R10 and R11 each independently represent H or C1-6alkyl; are tachykinin antagonists. They and compositions thereof are useful in medicine. |