| abstract |
Abstract of the Disclosure 2,4-Substituted 5-(N-substituted sulfamoyl)benzoylgua-nidines, process for their preparation, their use as drugs or diagnostic agents, and drugs in which they are present Benzoylguanidines of the formula I in which R(1) is R(4)R(5)N-C(X)-, where X is O, S or N-R(6), R(4) and R(5) are H or alk(en)yl(-R(7)) and R(7) is cycloalkyl or phenyl, or R(4) and R(5) together are 4 or 5 methylene groups, and R(6) is as defined for R(4) or is amidine, R(2) is H, Hal, (cyclo)alk(en)(yn)yl(alkyl), phenyl-(alkyl), an aromatic hydrocarbon, a heterocycle or -W-R(8), where W is oxygen, S or NR(9), and R(3) is H, Hal, alkyl or -W-R(8) as defined for R(2), and their pharmaceutically acceptable salts, are des-cribed. They are obtained by reacting a compound of formula II: II with guanidine. |